Protein Kinase A and Ca<sub>v</sub>1 (L-Type) Channels Are Common Targets to Facilitatory Adenosine A<sub>2A</sub> and Muscarinic M<sub>1</sub> Receptors on Rat Motoneurons
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چکیده
منابع مشابه
Anomalous L-Type Calcium Channels of Rat Spinal Motoneurons
Single channel patch-clamp recordings show that embryonic rat spinal motoneurons express anomalous L-type calcium channels, which reopen upon repolarization to resting potentials, displaying both short and long reopenings. The probability of reopening increases with increasing voltage of the preceding depolarization without any apparent correlation with inactivation during the depolarization. T...
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At the rat motor endplate, pre-synaptic facilitatory adenosine A 2A and muscarinic M 1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M 1 facilitation of [ 3 H]ACh release was partially recovered when CGS21680C (an A 2A agonist) was combined with the cyclic AMP antagonist Rp-cAMPS. Forsk...
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Voltage-dependent L-type Ca(2+) channels are multisubunit transmembrane proteins, which allow the influx of Ca(2+) (I:(Ca)) essential for normal excitability and excitation-contraction coupling in cardiac myocytes. A variety of different receptors and signaling pathways provide dynamic regulation of I:(Ca) in the intact heart. The present review focuses on recent evidence describing the molecul...
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ژورنال
عنوان ژورنال: Neurosignals
سال: 2005
ISSN: 1424-862X,1424-8638
DOI: 10.1159/000088642